Williams College Biologist Lara Hutson Wins $220,000 NIH Grant

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WILLIAMSTOWN - The National Institutes of Health (NIH) has awarded a two-year grant of $220,076 to Williams College Assistant Professor of Biology Lara D. Hutson, in support of her research on Charcot-Marie-Tooth disease or CMT.

CMT is the most common inherited neuromuscular disease, affecting as many as one in every 2,500 individuals. CMT usually shows dominant inheritance and symptoms generally appear during adolescence or young adulthood. It is characterized by degeneration of long motor and sensory axons, which results in muscle atrophy and skeletal deformities.

Hutson's research will use zebrafish as a model system to investigate disease mutations in two small heat shock proteins, HSP27 and HSPB8, which can cause either CMT or the closely related disease Distal Hereditary Motor Neuropathy (dHMN). The results of these studies will help to better understand the cell biological events leading to axon degeneration in CMT and dHMN.

Since these diseases are likely determined, at least in part, by environmental factors, the results of these studies could have implications for the prevention and management of these diseases.

Hutson received her B.A. from the University of California at San Diego and her Ph.D. from the University of Washington. She did her postdoctoral work in neurobiology and anatomy at the University of Utah.
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Williamstown Planning Board Narrowing in on Subdivision Bylaw Changes

By Stephen DravisiBerkshires Staff
WILLIAMSTOWN, Mass. — The Planning Board late last month discussed specific features of what it plans to pass as a new subdivision control bylaw this year.
 
The board long has discussed the complex set of regulations as being out of date and cumbersome to both potential developers and the board itself, which has needed to hear requests for waivers of outdated rules for the handful of residential subdivisions that have been proposed in town in recent years.
 
This spring, the town engaged consultants from Northampton's Dodson and Flinker Landscape Architecture and Planning to go through the existing bylaw, compare it to more contemporary regulations in other communities and help craft a revised bylaw.
 
Unlike the zoning bylaw, where amendments require approval of town meeting, the subdivision control bylaw is a creation of the Planning Board, which can make changes on its own after a public hearing process it hopes to complete this year.
 
At a special Planning Board meeting on May 26, Dillon Sussman of Dodson and Flinker and his colleagues walked the board through a dozen different decision points that the board must resolve — either by leaving the bylaw as is or making a change — and offered suggestions based on best practices.
 
All of the issues are technical and ranged from the fundamental, like how the bylaw will define types of subdivisions, to the highly specific, like what turning radii will be required in new streets that are constructed to serve planned developments.
 
One example of a topic that came up in the recent approval of a four-home subdivision off Summer Street is stormwater management.
 
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